Activation of Metabotropic Glutamate Receptor (mGlu2) and Muscarinic Receptors (M1, M4, and M5), Alone or in Combination, and Its Impact on the Acquisition and Retention of Learning in the Morris Water Maze, NMDA Expression, and cGMP Synthesis

The Morris water maze (MWM) is regarded as one of the most popular tests for detecting spatial memory in rodents. Long-term potentiation and cGMP synthesis seem to be among crucial factors involved this type learning. Muscarinic (M1, M4, M5 receptors) metabotropic glutamate (mGlu) receptors are important targets search antipsychotic drugs with potency treat cognitive disabilities associated disorder. Here, we show that muscarinic receptor activators (VU0357017, VU0152100, VU0238429) an mGlu2 activator, LY487379, dose-dependently prevented development disorders a result MK-801 administration MWM. dose-ranges compounds were follows: VU0357017, 0.25, 0.5, 1 mg/kg; 0.05, VU0238429, 1, 5, 20 3, 5 mg/kg. co-administration LY487379 each individual ligands showed no synergistic effect, which contradicts results obtained earlier novel object recognition (NOR) test. MWM learning resulted increased synthesis, both cortex hippocampi, when compared intact animals, was by administration. investigated at highest doses reversed MK-801-induced effect. Neither procedure nor treatment changes GluN2B-NMDA expression.